Semen analysis and treatment risk factors in long-term survivors of childhood cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10416581" target="_blank" >RIV/00064203:_____/21:10416581 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/21:10416581

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pn.1BuzS3b" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=pn.1BuzS3b</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/and.13853" target="_blank" >10.1111/and.13853</a>

Result language

angličtina

Original language name

Semen analysis and treatment risk factors in long-term survivors of childhood cancer

Original language description

The objective of this study was to compare semen quality (sperm density, progressive motility and spermia) between long-term childhood cancer survivors and a control group of males. The second objective was to correlate the semen analysis of the survivors with cancer treatment and endocrine status. The semen quality of 143 survivors (median age, 23.6 years) was compared to 200 men (median age, 27.9 years) who had not been diagnosed with cancer. The cancer-related risk factors and gonadotrophin levels were compared. Overall, 65% of the survivors had abnormal semen analysis compared to 26.5% of the controls (p &lt; 0.0001). Survivors with nonaspermia had lower sperm density than the controls (p &lt; 0.001). Other observed correlations were not significant. Survivors who were treated with alkylating agents were more likely to have abnormal semen analysis (p &lt; 0.008). Follicle-stimulating hormone and luteinising hormone levels were significantly elevated (p &lt; 0.0001) in survivors with abnormal semen analysis. The semen quality parameters, except for low sperm density, did not differ in survivors with nonaspermia compared to the controls. The risk factors included treatment with alkylating agents. Elevated gonadotrophin levels correlated with abnormal semen analysis. All cancer survivors should be made aware of the possibility of suffering from cancer treatment-related infertility.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NV19-03-00245" target="_blank" >NV19-03-00245: Signs of accelerated aging as late effect of therapy for childhood cancer and as risk factor of subsequent malignant neoplasms.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Andrologia

ISSN

0303-4569

e-ISSN

—

Volume of the periodical

53

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

e13853

UT code for WoS article

000578991200001

EID of the result in the Scopus database

2-s2.0-85092646905