Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10425204" target="_blank" >RIV/00064203:_____/21:10425204 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/21:10425204

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MJwWXUL1Fa" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MJwWXUL1Fa</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpeds.2021.02.060" target="_blank" >10.1016/j.jpeds.2021.02.060</a>

Result language

angličtina

Original language name

Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex

Original language description

To correlate fetal brain MRI findings with epilepsy characteristics and neurodevelopment at two years of age in children with Tuberous Sclerosis Complex (TSC) in order to improve prenatal counseling STUDY DESIGN: This retrospective cohort study was performed in a collaboration between centers of the EPISTOP consortium. We included children with definite TSC, fetal MRIs, and available follow-up data at two years of age. A pediatric neuroradiologist masked to the patient&apos;s clinical characteristics evaluated all fetal MRIs. MRIs were categorized for each of the ten brain lobes as score 0: no (sub)cortical lesions or doubt; score 1: a single small lesion; score 2: more than one small lesion or at least one large lesion (&gt; 5mm). Neurological manifestations were correlated to lesion sum scores RESULTS: Forty-one children were included. Median gestational age at MRI was 33.3 weeks; (sub)cortical lesions were detected in 97.6%. Mean lesion sum score was 4.5. At two years, 58.5% of patients had epilepsy and 22% had drug-resistant epilepsy. Cognitive, language, and motor development were delayed in 38%, 81%, and 50% of patients, respectively. Autism spectrum disorder (ASD) was diagnosed in 20.5%. Fetal MRI lesion sum scores were significantly associated with cognitive and motor development, and with ASD diagnosis, but not with epilepsy characteristics CONCLUSION: Fetal cerebral lesion scores correlate with neurodevelopment and ASD at two years in children with TSC.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pediatrics

ISSN

0022-3476

e-ISSN

—

Volume of the periodical

233

Issue of the periodical within the volume

June

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

156-162

UT code for WoS article

000655264900030

EID of the result in the Scopus database

2-s2.0-85103563815