A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10433197" target="_blank" >RIV/00064203:_____/22:10433197 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/22:10433197 RIV/00216224:14740/22:00128828
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iL0TRFRqJn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iL0TRFRqJn</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41590-021-01030-z" target="_blank" >10.1038/s41590-021-01030-z</a>
Alternative languages
Result language
angličtina
Original language name
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
Original language description
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Immunology
ISSN
1529-2908
e-ISSN
1529-2916
Volume of the periodical
23
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
159-164
UT code for WoS article
000708815900001
EID of the result in the Scopus database
2-s2.0-85117437869