The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10435649" target="_blank" >RIV/00064203:_____/22:10435649 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/22:10435649

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bf.ItcO3id" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=bf.ItcO3id</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41431-021-01000-x" target="_blank" >10.1038/s41431-021-01000-x</a>

Result language

angličtina

Original language name

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Original language description

Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Human Genetics

ISSN

1018-4813

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

493-495

UT code for WoS article

000730874900001

EID of the result in the Scopus database

2-s2.0-85121535929