Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10435972" target="_blank" >RIV/00064203:_____/22:10435972 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h5uYCsqfRM" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h5uYCsqfRM</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/dom.14634" target="_blank" >10.1111/dom.14634</a>
Alternative languages
Result language
angličtina
Original language name
Dulaglutide and Incident Atrial Fibrillation or Flutter in patients with type 2 Diabetes; a post-hoc analysis from the REWIND Randomized Trial
Original language description
AIMS: Diabetes mellitus is an independent risk factor for atrial fibrillation or atrial flutter (atrial arrythmia, AA). Additionally, some diabetes medications may influence AA incidence. The aim of this post hoc analysis was to assess the occurrence of AA during the study period in patients with type 2 diabetes treated with once weekly subcutaneous dulaglutide vs placebo in the REWIND study. MATERIALS AND METHODS: Patients without electrocardiographic (ECG) confirmed AA at baseline and randomised in the REWIND trial were assessed for the development of AA based on an annual ECG. Additional analyses included whether dulaglutide compared to placebo reduced the composite outcome of AA or death, AA or CV death, AA or stroke and AA or heart failure. RESULTS: Among 9543 participants (mean age 66 +- 7 years, with cardiovascular risk factors and 31% with previous cardiovascular disease) without AA at entry in the trial, 524 patients (5.5%) had at least one episode of AA during the median 5.4 years of follow-up. Incident AA occurred in 269 of the 4769 participants allocated to dulaglutide (5.6%), at a rate of 10.7 per 1000 person-years, vs. 255 of the 4774 allocated to placebo (5.3%) at a rate of 10.5 per 1000 person-years (p=0.59). There was also no effect of dulaglutide on the composite outcome of AA and death or AA and heart failure. CONCLUSION: This post hoc analysis of data from the REWIND trial showed that treatment with dulaglutide was not associated with a reduced incidence of AA in this at-risk group of patients with type 2 diabetes. This article is protected by copyright. All rights reserved.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes, Obesity & Metabolism
ISSN
1462-8902
e-ISSN
1463-1326
Volume of the periodical
24
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
704-712
UT code for WoS article
000746220400001
EID of the result in the Scopus database
2-s2.0-85123496387