Impact of liver fibrosis and nodules formation on hemodynamics in young adults after total cavopulmonary connection. A magnetic resonance study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10447009" target="_blank" >RIV/00064203:_____/22:10447009 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/22:10447009
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vxL8UqnA9X" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=vxL8UqnA9X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcvm.2022.986653" target="_blank" >10.3389/fcvm.2022.986653</a>
Alternative languages
Result language
angličtina
Original language name
Impact of liver fibrosis and nodules formation on hemodynamics in young adults after total cavopulmonary connection. A magnetic resonance study
Original language description
Background: The aim of this study was to analyze the relation between the hepatic fibrosis markers, liver morphology and hemodynamics assessed by magnetic resonance imaging (MRI) after total cavopulmonary connection (TCPC). Methods: Adult patients after TCPC performed in childhood between 1993 and 2003 are the subjects of this observational study. The follow-up protocol consisted of clinical and echocardiographic examination, liver elastography, cardiopulmonary exercise test, MRI hemodynamics and liver morphology assessment and direct enhanced liver fibrosis (ELF) test. Results: The cohort consisted of 39 patients (46% female) with a median age at study 26 (IQR 23 28) years and interval from TCPC 21 (IQR 20 - 23) years. There was no correlation between ELF test and any MRI variables, but procollagen III amino-terminal peptide (PIIINP), a single component of ELF test, correlated significantly with ventricular end-diastolic volume (r = 0.33; p = 0.042) and inferior vena cava flow (r = 0.47; p = 0.003). Fifteen (38%) patients with liver nodules had compared to other 24 patients higher end diastolic volume (ml/m2) 102.8 +- 20.0 vs 88.2 +- 17.7; p = 0.023 respectively. PIIINP correlated significantly with inferior vena cava flow (r = 0.56; p = 0.030) and with end diastolic volume (r = 0.53; p = 0.043), but only in patients with liver nodules. Conclusions: Gradual progression of liver fibrosis, particularly hepatic arterialization caused by liver nodules formation, increases inferior vena cava flow and subsequent ventricular volume overload may further compromise single ventricle functional reserve in adult patients after TCPC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cardiovascular Medicine [online]
ISSN
2297-055X
e-ISSN
2297-055X
Volume of the periodical
2022
Issue of the periodical within the volume
September
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
986653
UT code for WoS article
000868517200001
EID of the result in the Scopus database
2-s2.0-85139998278