Diagnostic challenges and treatment options in patients with solitary fibrous tumor: A single-center observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10449327" target="_blank" >RIV/00064203:_____/22:10449327 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10449327 RIV/00216208:11130/22:10449327

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Rdm4cB_fCp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Rdm4cB_fCp</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fsurg.2022.952463" target="_blank" >10.3389/fsurg.2022.952463</a>

Result language

angličtina

Original language name

Diagnostic challenges and treatment options in patients with solitary fibrous tumor: A single-center observational study

Original language description

INTRODUCTION: Solitary fibrous tumor (SFT) is an extremely rare disease with a high misdiagnosis rate and a potentially malignant biologic nature. We have collected and analyzed data from 18 SFT patients to provide a deeper insight into this uncommon disease entity. METHODS: In our study, 18 patients who had undergone surgery between April 2014 and December 2021 for the diagnosis of SFT were evaluated. The collected data for each patient included the location of the SFT, the preoperative diagnosis, the definitive histological diagnosis, the presence of postoperative complications, the time of recurrence, the time of systemic progression, the type of treatment, and the survival rate. The median follow-up was 36 months. RESULTS: In three patients, the preoperative diagnosis did not correlate with the definitive histology of SFT. In patients with the limb location of SFT, no signs of recurrence nor distant metastases were seen within the study period. In total, 50% of the postsurgical complications were associated with the abdominal location of the SFT. In newly diagnosed SFT patients, two patients (20%) developed local recurrence, and the median time until recurrence was 22.5 months. Out of patients that were admitted and operated on for recurrent SFT, 67% relapsed, and the median time to relapse was 9.5 months. The systemic progression of the disease was observed in 33% of patients treated for recurrent SFT. CONCLUSION: In our study, the misdiagnosis rate was high and correlated with previously published studies. Postsurgical complications were associated with the extrathoracic location of SFT. The mainstay of SFT treatment remains radical surgery, although radiotherapy alone can significantly improve overall survival. Clinical trials are urgently needed to evaluate the potential effect of other treatment modalities, such as immunotherapy and targeted therapy, in SFT patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Surgery

ISSN

2296-875X

e-ISSN

2296-875X

Volume of the periodical

9

Issue of the periodical within the volume

August

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

952463

UT code for WoS article

000875611600001

EID of the result in the Scopus database

2-s2.0-85140470679