Autoantibodies against type I IFNs in patients with critical influenza pneumonia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10459862" target="_blank" >RIV/00064203:_____/22:10459862 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/22:10459862
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f4im7U8Ngs" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=f4im7U8Ngs</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1084/jem.20220514" target="_blank" >10.1084/jem.20220514</a>
Alternative languages
Result language
angličtina
Original language name
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Original language description
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 x 10-5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 x 10-5), especially those <70 yr old (OR = 139.9, P = 3.1 x 10-10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for TILDE OPERATOR+D915% of cases of life-threatening influenza pneumonia in patients <70 yr old.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Medicine
ISSN
0022-1007
e-ISSN
—
Volume of the periodical
219
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
29
Pages from-to
e20220514
UT code for WoS article
000890308700001
EID of the result in the Scopus database
2-s2.0-85136198376