Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10450557" target="_blank" >RIV/00064203:_____/23:10450557 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/23:00574564 RIV/61388971:_____/23:00574564 RIV/00216208:11130/23:10450557
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hY8CvWdQkN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hY8CvWdQkN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/bloodadvances.2021006431" target="_blank" >10.1182/bloodadvances.2021006431</a>

Result language
angličtina
Original language name
Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy
Original language description
L-asparaginase (ASNase), the drug included on the World Health Organization's List of EssentialMedicines, is irreplaceable in the front-line treatment of childhood acute lymphoblastic leukemia(ALL)1 . However, the relapse of ALL is often associated with resistance to ASNase and itsmechanisms are not fully understood. The cytotoxic effect of ASNase relies on depleting exogenousasparagine (Asn) and glutamine (Gln), inducing apoptosis in leukemic cells because of their reducedcapability of Asn synthesis. Our previous in vitro data demonstrated that ASNase triggers metabolicreprogramming of leukemic cells which impedes the anti-leukemic effect. Metabolic processes ofleukemic cells have been shown to be altered by the environment of the bone marrow (BM) whichmay contribute to chemoresistance. Herein, we investigated the impact of BM attributes oncellular metabolic processes of leukemic cells in order to demonstrate the more complex picture ofASNase-driven metabolic rewiring and its role in the mechanism of resistance.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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