Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10457372" target="_blank" >RIV/00064203:_____/23:10457372 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10457372
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=71XXil1WZc" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=71XXil1WZc</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41409-023-01942-4" target="_blank" >10.1038/s41409-023-01942-4</a>

Result language
angličtina
Original language name
Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft
Original language description
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disease of early childhood. More than 90% of patients harbor mutations in PTPN11, KRAS, NRAS, CBL, or NF1. For most patients, allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy, while relapse is the major cause of treatment failure recorded in about 35% of patients. Age >=2 years, high hemoglobin F (HbF), secondary clonal aberrations, and DNA hypermethylation are associated with an increased risk of relapse. Treatment options for recurrent JMML are limited; for patients still on immunosuppressive therapy, discontinuation of all immunosuppressing agents is generally the first intervention. Donor leukocyte infusions (DLI) can induce a response in some relapsed patients, but the overall outcome of DLI as single strategy has been unfavorable. Few data are available on the efficacy and safety of second HSCT in JMML. We analyzed the outcome of 68 children with JMML who relapsed after first HSCT and received a second allograft.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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