Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10464980" target="_blank" >RIV/00064203:_____/23:10464980 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10464980
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yYMHEnbWcE" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yYMHEnbWcE</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ajt.2023.06.003" target="_blank" >10.1016/j.ajt.2023.06.003</a>
Alternative languages
Result language
angličtina
Original language name
Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies
Original language description
In lung transplantation, antibody-mediated rejection (AMR) diagnosed by ISHLT criteria is uncommon compared to other organs, and previous studies failed to find molecular AMR (ABMR) in lung biopsies. However, understanding of ABMR has changed with the recognition that ABMR in kidney transplants is often DSA-negative and associated with NK cell transcripts. We therefore searched for a similar molecular ABMR-like state in transbronchial biopsies (TBBs) using gene expression microarray results from the INTERLUNG study (#NCT02812290). After optimizing rejection-selective transcript sets (RSTS) in a training set (n = 488), the resulting algorithms separated an NK cell-enriched rejection-like state (NKRL) from TCMR/Mixed in a test set (n = 488). Applying this approach to all 896 TBBs distinguished three groups - No rejection; TCMR/Mixed; and NKRL. Like TCMR/Mixed, NKRL had increased expression of all-rejection transcripts, but NKRL had increased expression of NK cell transcripts, whereas TCMR/Mixed had increased effector T cell and activated macrophage transcripts. NKRL was usually DSA-negative and not recognized as AMR clinically. TCMR/Mixed was associated with CLAD, reduced FEV1, and short-term graft failure, but NKRL was not. Thus, some lung transplants manifest a molecular state similar to DSA-negative ABMR in kidney and heart transplants, but its clinical significance must be established.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Transplantation
ISSN
1600-6135
e-ISSN
1600-6143
Volume of the periodical
23
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1922-1938
UT code for WoS article
001165316200001
EID of the result in the Scopus database
2-s2.0-85162889615