Effect of metoprolol in hypertrophic obstructive cardiomyopathy patients after alcohol septal ablation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10472211" target="_blank" >RIV/00064203:_____/23:10472211 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10472211
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=N4Ld9UZMZJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=N4Ld9UZMZJ</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijcha.2023.101317" target="_blank" >10.1016/j.ijcha.2023.101317</a>
Alternative languages
Result language
angličtina
Original language name
Effect of metoprolol in hypertrophic obstructive cardiomyopathy patients after alcohol septal ablation
Original language description
Background: The use of beta-blockers in hypertrophic obstructive cardiomyopathy (HOCM) patients after alcohol septal ablation (ASA) lacks data support. We aimed to evaluate the effect of metoprolol on exercise capacity, hemodynamic and laboratory parameters, and quality of life in HOCM patients after ASA. Methods: This was a prospective randomized single-center open-label crossover trial in 21 HOCM patients after ASA. Patients received metoprolol and no beta-blocker for two periods of three months. The endpoints were: peak oxygen uptake (pVO2), maximal left ventricular outflow tract (LVOT) pressure gradient at peak exercise, a ratio of mitral peak velocity of the early filling (E) to early diastolic mitral annular velocity (e') (E/e') at rest, Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score, and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) plasmatic concentration. Results: No significant association was found between the treatment and any of the endpoints in the assessed patients: 1) pVO2 (19.5 +- 5.3 ml/kg/min vs. 19.4 +- 4.1 ml/kg/min, p = 0.90), 2) exercise-induced pressure gradient in LVOT 32 +- 37 mmHg vs. 32 +- 30 mmHg, p = 0.84, 3) E/e' ratio at rest (11 +- 4 vs. 10 +- 4, p = 0.23), 4) KCCQ overall summary score (78 +- 11 vs. 77 te +- 15, p = 0.56), 5) NT-proBNP (215 pg/ml [121-333] vs. 153 pg/ml [102-228], p = 0.19). Conclusions: In HOCM patients after successful ASA, metoprolol treatment did not improve exercise capacity, hemodynamic and laboratory parameters, or quality of life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Cardiology. Heart & Vasculature
ISSN
2352-9067
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
101317
UT code for WoS article
001131540800001
EID of the result in the Scopus database
2-s2.0-85178573911