Cyclosporin A in combination with corticosteroids as a treatment for immunoglobulin A vasculitis nephritis in children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10458587" target="_blank" >RIV/00064203:_____/25:10458587 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10458587

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sVsPkkZtCN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sVsPkkZtCN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S2724-5276.23.07057-X" target="_blank" >10.23736/S2724-5276.23.07057-X</a>

Result language

angličtina

Original language name

Cyclosporin A in combination with corticosteroids as a treatment for immunoglobulin A vasculitis nephritis in children

Original language description

BACKGROUND: Immunoglobulin A vasculitis is the most common vasculitis in children. It is usually a self-limiting condition, and the long-term prognosis depends on the severity of renal involvement. Although cyclosporin A is not generally recommended for the management of moderate immunoglobulin A vasculitis nephritis, a few previous reports showed its efficacy. Our aim was to determine whether the treatment with cyclosporin A in combination with corticosteroids is safe and effective for moderate pediatric immunoglobulin A vasculitis nephritis. METHODS: Nine children underwent treatment. Mean follow-up was 3.1+-1.6 (1.4-5.8) years. RESULTS: All children (seven females and two males) reached complete remission (65.8+-27.6 [24-99]) days. No patient had relapse, one patient had slightly impaired kidney function (glomerular filtration rate 84.4 mL/min/1.73 m(2)), and two patients had microscopic hematuria without proteinuria at last follow-up. One patient with delayed treatment had microscopic hematuria at last follow-up and developed early albuminuria after cessation of immunosuppression. We observed no serious complications or side effects of the treatment. CONCLUSIONS: Cyclosporin A in combination with corticosteroids seems to be a safe and effective treatment for moderate immunoglobulin A vasculitis nephritis. More studies with cyclosporin A should be conducted to better determine the best therapeutic approach.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Minerva Pediatrics

ISSN

2724-5276

e-ISSN

2724-5780

Volume of the periodical

77

Issue of the periodical within the volume

6

Country of publishing house

IT - ITALY

Number of pages

6

Pages from-to

500-505

UT code for WoS article

001146082500001

EID of the result in the Scopus database

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