Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10487405" target="_blank" >RIV/00064203:_____/25:10487405 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10487405
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Xe5Axv5pl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Xe5Axv5pl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cmi.2024.11.007" target="_blank" >10.1016/j.cmi.2024.11.007</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Pseudomonas aeruginosa carriage on intensive care unit-acquired pneumonia: a European multicentre prospective cohort study
Original language description
OBJECTIVES: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the ICU. The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify its independent association with PA colonisation at different body sites. METHODS: Adult patients on mechanical ventilation at ICU admission were prospectively enrolled across 30 European ICUs. PA colonisation in the perianal area and in the lower respiratory tract were assessed within 72 hours after ICU admission and twice weekly until ICU discharge. PAIP development was evaluated daily. Competing risk models with colonisation as a time-varying exposure and ICU death and discharge as competing events were fitted and adjusted for confounders to investigate the association between PA carriage and PAIP. RESULTS: 1971 subjects were enrolled. The colonisation prevalence with P. aeruginosa in the first 72 hours of ICU admission was 10.4% (179 perianal, 51 respiratory), while the acquisition incidence during the ICU stay was 7.0% (158 perianal, 47 respiratory). Of the 43 (1.8%) patients who developed PAIP, 11 (25.6%) were PA colonised on admission and 9 (20.9%) acquired colonisation prior to PAIP onset. Both perianal (adjusted sub distribution hazard ratio [aSHR] 4.4, 95%CI 1.7-11.6) and respiratory colonisation (aSHR 4.6, 95%CI 1.9-11.1) were independently associated with PAIP development. CONCLUSIONS: PAIP incidence was higher in PA colonised vs non-colonised patients. Both colonisation of the rectum and of the respiratory tract were associated with development of PAIP. The increased risk of P. aeruginosa colonisation for subsequent infection provides an opportunity for targeted preventive interventions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Microbiology and Infection
ISSN
1198-743X
e-ISSN
1469-0691
Volume of the periodical
31
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
433-440
UT code for WoS article
001435228300001
EID of the result in the Scopus database
2-s2.0-85211967558