Donor cytomegalovirus serology impacts overall survival in children receiving first unrelated hematopoietic stem cell transplant for acute leukemia: European Society of Bone Marrow Transplantation Pediatric Diseases Working Party Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10487954" target="_blank" >RIV/00064203:_____/25:10487954 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10487954
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=raDP.In0pk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=raDP.In0pk</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2024.286082" target="_blank" >10.3324/haematol.2024.286082</a>
Alternative languages
Result language
angličtina
Original language name
Donor cytomegalovirus serology impacts overall survival in children receiving first unrelated hematopoietic stem cell transplant for acute leukemia: European Society of Bone Marrow Transplantation Pediatric Diseases Working Party Study
Original language description
This is a retrospective study of pseudonymized clinical data reported to the EuropeanSociety for Blood and Marrow Transplantation (EBMT) registry. The study was approved bythe Pediatric Diseases Working Party (PDWP) of the EBMT institutional review board andconducted in accordance with the Declaration of Helsinki. Children (age <18y) with acutemyeloid (AML) or lymphoblastic leukemia (ALL) receiving the first allogeneic HSCT between2005 and 2021 were included. All patients received a bone marrow or peripheral bloodtransplant from an HLA-matched unrelated donor (10/10 at loci A, B, C, DRB1 and DQB1 inhigh resolution) uniformly. Transplant procedures using in vivo T-cell depletion (ATG oralemtuzumab) were included. Cord-blood transplantation, transplant procedures involving exvivo T-cell depletion or PTCy were excluded. The primary objective was to assess the impactof donor CMV serology on overall survival (OS) in pediatric HSCT recipients with AML orALL. The secondary objectives were the comparison of leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse incidence (RI), incidence of both acute graft versus hostdisease (aGvHD) and chronic GvHD (cGvHD), and GvHD-free/relapse-free survival (GRFS)between the seropositive (D+) and seronegative (D-) donor groups.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
1592-8721
Volume of the periodical
110
Issue of the periodical within the volume
4
Country of publishing house
IT - ITALY
Number of pages
5
Pages from-to
985-989
UT code for WoS article
001495075900017
EID of the result in the Scopus database
2-s2.0-105001675505