Effect of epidural spinal cord stimulation in individuals with sensorimotor complete spinal cord injury: a pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10499700" target="_blank" >RIV/00064203:_____/25:10499700 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10499700
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yY1mMprZ4F" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yY1mMprZ4F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnsys.2025.1622033" target="_blank" >10.3389/fnsys.2025.1622033</a>
Alternative languages
Result language
angličtina
Original language name
Effect of epidural spinal cord stimulation in individuals with sensorimotor complete spinal cord injury: a pilot study
Original language description
Spinal cord injury (SCI) often results in irreversible sensorimotor and autonomic dysfunction, severely limiting independence and quality of life. Individuals with clinically complete SCI (AIS A) have traditionally been considered beyond functional recovery. This pilot study aimed to evaluate the therapeutic potential and broader impact of epidural spinal cord stimulation (eSCS) on this population. Three participants with chronic, sensorimotor complete thoracic SCI received implantation of a 32-contact epidural stimulator targeting the lumbosacral spinal cord. Personalized stimulation protocols were developed to support lower limb activation and upright posture. Motor, autonomic, and quality of life outcomes were assessed over a 12-month follow-up. All participants achieved independent standing through eSCS-enabled muscle activation, despite the absence of voluntary movement. The intervention led to improvements in postural control and trunk stability, as well as clinically meaningful gains in autonomic functions, including bladder, bowel, and sexual health, alongside reductions in spasticity and neuropathic pain. Importantly, participants reported sustained and substantial improvements in their perceived quality of life. This study provides evidence that eSCS can restore key functional capacities and significantly enhance the quality of life for individuals with sensorimotor complete SCI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30306 - Sport and fitness sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Systems Neuroscience
ISSN
1662-5137
e-ISSN
1662-5137
Volume of the periodical
19
Issue of the periodical within the volume
July
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
1622033
UT code for WoS article
001529342200001
EID of the result in the Scopus database
2-s2.0-105011344308