Separation and Analysis of Methicillin-sensitive and Resistant Staphylococcus Strains Using Vancomycin-modified Magnetic Nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10504269" target="_blank" >RIV/00064203:_____/25:10504269 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43510/25:43927557 RIV/00216208:11130/25:10504269
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RBC81ah25Q" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RBC81ah25Q</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/sscp.70135" target="_blank" >10.1002/sscp.70135</a>
Alternative languages
Result language
angličtina
Original language name
Separation and Analysis of Methicillin-sensitive and Resistant Staphylococcus Strains Using Vancomycin-modified Magnetic Nanoparticles
Original language description
Multi-resistant bacterial strains pose a serious threat in the hospital environment. Management of nosocomial infections requires completely new approaches. Vancomycin (Vanco) is a known antibiotic for the treatment of serious infections, including those caused by methicillin-resistant Staphylococcus aureus strains. Nanomedicine brings new possibilities, including targeting using surface modifications of nanoparticles (NPs). Superparamagnetic iron oxide NPs (SPIONs) are synthetic nanomaterials with unique magnetic properties that are widely used in nanomedicine. They are primarily used in diagnostic imaging, targeted drug delivery, and therapy. Minimal inhibition concentration was determined to be 150 µg/mL. For the purpose of this study, SPIONs were modified with chitosan and then purified on a magnet. After washing with buffer, the particles were modified with Vanco (100 µg/mL). The stability of modified NPs was verified by Vanco analysis using high-performance liquid chromatography. Bacterial cultures were grown reproducibly in a pure medium. Subsequently, antibacterial activity was monitored by growth curves (S. aureus) that were measured at 450 nm/540 nm for 24 h, repeated in four cycles. The results were evaluated as the area under the growth curves. The study provides initial insights into the effects of newly synthesized NP variants on S. aureus.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Separation Science Plus
ISSN
2573-1815
e-ISSN
2573-1815
Volume of the periodical
8
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
e70135
UT code for WoS article
001605964600005
EID of the result in the Scopus database
2-s2.0-105018604416