Arrhythmogenic Toxicity in Radiotherapy: Cardiac Conduction System as an Emerging Organ at Risk

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10504277" target="_blank" >RIV/00064203:_____/25:10504277 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10504277

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9J80EITHxq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9J80EITHxq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-025-00356-6" target="_blank" >10.1007/s44411-025-00356-6</a>

Result language

angličtina

Original language name

Arrhythmogenic Toxicity in Radiotherapy: Cardiac Conduction System as an Emerging Organ at Risk

Original language description

BackgroundCardiovascular disease is the most common non-oncologic cause of death in patients treated with radiotherapy in thoracic region. Radiation-induced heart disease (RIHD) includes a range of structural and functional complications, among which arrhythmogenic toxicity-conduction disorders and arrhythmias-has gained increasing attention. The cardiac conduction system is not routinely delineated as an organ at risk (OAR), nor are the surrounding structures such as the pulmonary veins, which represent a key pathophysiological site in the development of supraventricular arrhythmias. Traditional parameters like mean heart dose (MHD) may not adequately reflect regional radiosensitivity, particularly in anatomically distinct substructures located at the base of the heart, such as the sinoatrial (SA) and atrioventricular (AV) nodes.AimThis review summarizes current evidence on the effects of radiotherapy on the cardiac conduction system and highlights emerging data on its role in arrhythmogenic toxicity.ConclusionRadiation-induced arrhythmias can occur early after treatment. The heart&apos;s heterogeneous radiosensitivity challenges the use of mean heart dose (MHD) as a predictive metric. Recent studies suggest that cardiac substructures, especially the base of the heart, may be critical regions. A shift toward substructure-specific dosimetry is needed. Recently, arrhythmogenic cardiotoxicity has attracted greater interest in lung cancer, as improvements in overall survival with immunotherapy and targeted agents have increased the relevance of long-term treatment-related toxicities, including radiation-induced arrhythmias.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Volume of the periodical

126

Issue of the periodical within the volume

12

Country of publishing house

SK - SLOVAKIA

Number of pages

13

Pages from-to

3306-3318

UT code for WoS article

001591965200001

EID of the result in the Scopus database

2-s2.0-105018778529