Surgical strategies for radical resections in subaxial cervical spine tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10505502" target="_blank" >RIV/00064203:_____/25:10505502 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10505502 RIV/00216208:11130/25:10505502
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eOaBaE7Lh7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eOaBaE7Lh7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bas.2025.105629" target="_blank" >10.1016/j.bas.2025.105629</a>
Alternative languages
Result language
angličtina
Original language name
Surgical strategies for radical resections in subaxial cervical spine tumors
Original language description
Background: Radical resection of subaxial cervical spine tumors is challenging. This study evaluates outcomes following these extensive procedures. Methods: We retrospectively reviewed 24 patients (mean age 38.8 yrs) treated (2002-2022) for subaxial cervical tumors (8 benign, 10 primary malignant, 6 metastatic). Procedures included total en bloc spondylectomy (TES, n = 9), total piecemeal spondylectomy (TPS, n = 6), and en bloc tumor resection (ETR, n = 9). Outcomes assessed included radiographic fusion, functional status (Visual Analog Scale [VAS]/Neck Disability Index [NDI]), complications, local recurrence, and survival. Paired t-tests and Kaplan-Meier/log-rank tests were used for statistical analysis. Results: Mean follow-up was 62 months. Benign tumor patients (ETR) experienced no recurrences or major complications and showed significant VAS/NDI improvement (p < 0.05). Primary malignant tumor patients (TES/TPS/ETR) had no local recurrence but suffered higher mortality (6/10 deaths; 4 disease-related) and complications (vertebral artery injury, cerebrospinal fluid leak, nerve injury), along with significant VAS/NDI improvement (p < 0.05). Metastatic tumor patients (TES/TPS) had no local recurrence or intraoperative complications; 50 % of these patients died from systemic disease. Significant VAS/NDI improvement was also achieved (p < 0.05). Radiographic fusion was confirmed in all the patients where bone grafts were applied (n = 21). Overall survival differed significantly by tumor type (p = 0.0395), with a significant trend across groups (p = 0.0340). Conclusion: Radical resection for selected subaxial cervical tumors achieved high fusion rates, significant functional improvement, and excellent local tumor control. However, inherent risks of severe complications exist, particularly with malignant tumors. Survival varied significantly by histology. Current data preclude definitive conclusions on the comparative oncological efficacy of en bloc versus piecemeal techniques.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain and Spine
ISSN
2772-5294
e-ISSN
2772-5294
Volume of the periodical
5
Issue of the periodical within the volume
2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
105629
UT code for WoS article
001619817600001
EID of the result in the Scopus database
2-s2.0-105021523660