Cell cycle inhibitor p21/WAF1/CIP1 as a cofactor of MITF expression in melanoma cells.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F10%3A%230000067" target="_blank" >RIV/00064211:_____/10:#0000067 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cell cycle inhibitor p21/WAF1/CIP1 as a cofactor of MITF expression in melanoma cells.

Original language description

p21/WAF1/Cip1 (p21), a cyclin dependent kinase inhibitor, may act as an antioncogene, but may also behave as a tumor promoting factor by inhibiting apoptosis. Here we show that the p21 protein positively regulates the promoter of MITF, a transcription factor which plays a central role in the expression of melanocyte-specific genes, lineage determination, and survival of melanoma cells. Our results might help explain the tolerance of increased p21 levels found in some melanomas.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9319" target="_blank" >NR9319: Altered function and composition of the chromatin-remodeling complex SWI/SNF in the progression of lung carcinoma and melanoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pigment cell & melanoma research

ISSN

1755-1471

e-ISSN

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Volume of the periodical

23

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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