Economic evaluation of rFVIIa high initial dose compared to rFVIIa standard initial dose in patients with haemophilia with inhibitors using the Czech HemoRec

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F14%3A%230000299" target="_blank" >RIV/00064211:_____/14:#0000299 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.thromres.2013.11.002" target="_blank" >http://dx.doi.org/10.1016/j.thromres.2013.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.thromres.2013.11.002" target="_blank" >10.1016/j.thromres.2013.11.002</a>

Result language

angličtina

Original language name

Economic evaluation of rFVIIa high initial dose compared to rFVIIa standard initial dose in patients with haemophilia with inhibitors using the Czech HemoRec

Original language description

In the treatment of bleeds in haemophilia patients with inhibitors,a high initial dose of recombinant Factor VIIa (rFVIIa) provides at least equal efficacy and a similar safety profile to a standard initial dose. However, no pharmacoeconomic comparison between these dosing regimens has previously been performed. Here, we assess the pharmacoeconomics of high (>120 &#956;g/kg) versus standard (&#8804;120 &#956;g/kg) initial rFVIIa dose in inhibitor patients and the impact of time to treatment initiation on costs and outcomes.In a retrospective analysis, observational data on bleed characteristics, rFVIIa treatment, hospitalizations and outcomes were extracted from the Czech Republic HemoRec registry. Crude comparisons and generalized linear regression modelling (GLM; correcting for patient differences) were performed to compare costs and outcomes between the high and standard initial dosing groups.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis research

ISSN

0049-3848

e-ISSN

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Volume of the periodical

133

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

162-167

UT code for WoS article

000329572600007

EID of the result in the Scopus database

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