Contribution of the detection of IgA antibodies to the laboratory diagnosis of mumps in the population with a high vaccination coverage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F15%3A%230000465" target="_blank" >RIV/00064211:_____/15:#0000465 - isvavai.cz</a>

Result on the web

<a href="http://www.prolekare.cz/epidemiologie-clanek/prinos-stanoveni-protilatek-iga-pro-laboratorni-diagnostiku-priusnic-ve-vysoce-proockovane-populaci-51795" target="_blank" >http://www.prolekare.cz/epidemiologie-clanek/prinos-stanoveni-protilatek-iga-pro-laboratorni-diagnostiku-priusnic-ve-vysoce-proockovane-populaci-51795</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Contribution of the detection of IgA antibodies to the laboratory diagnosis of mumps in the population with a high vaccination coverage

Original language description

Study objective: Serological diagnosis of epidemic mumps can be difficult in vaccinated persons, particularly due to the absence of specific IgM antibodies. The aim was to find whether adding the detection of IgA antibodies to the currently used routine serological diagnosis of mumps (detection of IgM and IgG antibodies in an acute serum sample) would make the serological diagnosis of mumps more effective in a population with a high vaccination coverage. At the same time, ELISA kits for the detection of early IgA and IgM antibodies against the mumps virus were compared and statistical analysis of the results was performed. Results: The detection of IgA and IgM antibodies against the mumps virus yielded concordant results in 50/64 acute sera, 32 positive and 18 negative, i.e. an agreement of 78.12 %. Of the remaining 14 samples, 13 were only IgA positive and one was only IgM positive. The controls showed non-specific IgA positivity in 5/121 samples which indicates a 96% specificity.Conclusion: The absence of specific IgM antibodies against mumps virus is relatively often seen in vaccinated individuals; nevertheless, the test is routinely used in patients with suspected active infection. The test for IgA antibodies, which is not routinely performed, significantly increased the detection rate of the disease. Based on the results of the present study, it can be concluded that the combination of the anti-mumps IgM and IgA assays increased the effectiveness of the serological diagnosis at the onset of clinical symptoms from less than 52% to nearly 72%.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EPIDEMIOLOGIE MIKROBIOLOGIE IMUNOLOGIE

ISSN

1210-7913

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

16-19

UT code for WoS article

000353309200004

EID of the result in the Scopus database

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