Are Anti-TNF-alpha Agents Safe for Treating Psoriasis in Hepatitis C Virus Patients with Advanced Liver Disease? Case Reports and Review of the Literature

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F16%3AN0000004" target="_blank" >RIV/00064211:_____/16:N0000004 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10323725

Result on the web

<a href="http://dx.doi.org/10.1159/000439587" target="_blank" >http://dx.doi.org/10.1159/000439587</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000439587" target="_blank" >10.1159/000439587</a>

Result language

angličtina

Original language name

Are Anti-TNF-alpha Agents Safe for Treating Psoriasis in Hepatitis C Virus Patients with Advanced Liver Disease? Case Reports and Review of the Literature

Original language description

Tumor necrosis factor-alpha (TNF-alpha) inhibitors represent an effective treatment for severe psoriasis in hepatitis C virus (HCV) patients. The literature reports mainly on shortterm treatment in patients with chronic hepatitis with minimum-to-moderate activity with an acceptable safety profile. We report the first 2 cases of hepatocellular carcinoma (HCC) arising in HCV psoriatic patients with advanced liver disease during long-term treatment with etanercept. Our first patient, known to have had HCV infection for 41 years, developed an HCC after 21 months of therapy with etanercept (50 mg/week). The second patient, HCV+ for 20 years, was treated for 58 months with the same therapy, and despite no signs of liver function impairment was diagnosed with HCC. Both of them presented with cirrhosis, which was diagnosed 9 and 5 years earlier, respectively. It remains to be clarified whether there is any connection between psoriasis treatment with antiTNF-alpha agents and the development of HCC in HCV-infected patients. Further long-term, follow-up studies and registries of HCV patients with mild/moderate activity may contribute to clarify this issue. (C) 2015 S. Karger AG, Basel

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

DERMATOLOGY

ISSN

1018-8665

e-ISSN

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Volume of the periodical

232

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

102-106

UT code for WoS article

000370150600018

EID of the result in the Scopus database

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