Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F16%3AN0000035" target="_blank" >RIV/00064211:_____/16:N0000035 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10327988
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pubmed/27538636" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/27538636</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jns.2016.05.059" target="_blank" >10.1016/j.jns.2016.05.059</a>
Alternative languages
Result language
angličtina
Original language name
Prospective study on the chemokine CXCL13 in neuroborreliosis and other aseptic neuroinfections
Original language description
The study evaluates the clinical significance of CXCL13 (leukocyte chemoattractant synthesized in CSF) in Lyme neuroborreliosis (LNB) and other aseptic CNS infections. 244 patients with symptoms of neuroinfection and/or LNB were divided into groups: A - patients with LNB-positive antibodies in serum and CSF (96) or CSF only (14); B - patients with aseptic non-borrelial neuroinfections (82); C - negative controls (52). Group A was divided into A1-A4 according to pleocytosis in CSF and AIIgG positivity. The highest CSF CXCL13 concentrations (max. 81,287.60 pg/ml; median 1766.90 pg/ml) were in A1 (positive AI, pleocytosis) and A3 (negative AIIgG, pleocytosis; max. 7201,60 pg/ml, median 56.22 pg/ml). A2 ( positive AI without pleocytosis) and A4 (negative Al without pleocytosis) had low CXCL13 levels - A2 max. 650.50 pg/ml (median < 7.80 pg/ml); A4 max. 118.56 pg/ml (median < 7.8 pg/ml). In B the median was 28.10 pg/ml (max. 595.87 pg/ml). In C the CXCL13 concentrations were the lowest (max. 83.83 pg/ml; median < 7.80 pg/ml). The lowest cut-off was 29 pg/ml (sensitivity 90.0%, specificity 72.2%), the highest one 400 pg/ml (sensitivity 59.6%, specificity 94.0%). The group differences of serum CXCL13 were insignificant. The highest concentrations were at the beginning of the disease. In LNB CXCL13 correlates better with the CSF pleocytosis than AI positivity. (C) 2016 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13467" target="_blank" >NT13467: Tick-borne neuroinfection - clinical manifestations and diagnostic</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN
0022-510X
e-ISSN
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Volume of the periodical
368
Issue of the periodical within the volume
SEP 15 2016
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
214-220
UT code for WoS article
000382415700045
EID of the result in the Scopus database
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