The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F18%3AM0000104" target="_blank" >RIV/00064211:_____/18:M0000104 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10380499 RIV/00216208:11210/19:10380499 RIV/00216208:11140/19:10380499 RIV/00023752:_____/19:43919555 and 2 more

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/30306269/" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/30306269/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00737-018-0913-3" target="_blank" >10.1007/s00737-018-0913-3</a>

Result language

angličtina

Original language name

The effects of intrapartum synthetic oxytocin on maternal postpartum mood: findings from a prospective observational study

Original language description

Postpartum depression (PPD) affects up to 19% of all mothers, with detrimental effects on both mother and child. The antidepressant and anxiolytic effects of plasma oxytocin are well-documented, but it is still disputable whether synthetic oxytocin (synOT) may protect women against postpartum mood alterations. The current study examined the association between synOT intrapartum and maternal mood postpartum using a prospective design. Two hundred sixty women were screened for depressive symptoms in the last trimester of pregnancy and then again 6 weeks and 9 months postpartum using the Edinburgh Postnatal Depression Scale. They also completed Maternity Blues Questionnaire in the first postpartum week. The data concerning the intrapartum interventions and health status of the newborn were extracted from the medical records. Cox proportional hazards regression adjusted for a history of depression, mode of delivery, and childbirth experience showed that synOT predicted a significantly lower risk of PPD (HR = 0.65, 95% CI 0.45-0.95, p = 0.025). The risk factors for PPD included a history of depression (HR = 3.20, 95% CI 2.33-4.40, p < 0.001) and negative childbirth experience (HR = 1.39, 95% CI 1.01-1.90, p = 0.040). Logistic regression adjusted for the same covariates found no significant effect of synOT on maternity blues (OR = 0.64, 95% CI 0.31-1.32, p = 0.23). While synOT administered intrapartum does not affect maternal mood immediately, it may come to effect some weeks after childbirth to protect mothers from developing PPD symptoms.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

<a href="/en/project/GA17-10464S" target="_blank" >GA17-10464S: Perinatal risk factors, maternal competences and child development - A prospective study from prenatal period to pre-school age</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of women's mental health

ISSN

1434-1816

e-ISSN

1435-1102

Volume of the periodical

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Issue of the periodical within the volume

2018 Oct 10

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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