Long-term results of radio(chemo)therapy in metastatic carcinoma to cervical lymph nodes from an unknown primary. Adult Comorbidity Evaluation 27 score as a predictor of survival

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F23%3AW0000003" target="_blank" >RIV/00064211:_____/23:W0000003 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10445975 RIV/00064211:_____/23:W0000052 RIV/00064165:_____/23:10445975

Result on the web

<a href="https://dx.doi.org/10.1007/s00066-022-01983-6" target="_blank" >https://dx.doi.org/10.1007/s00066-022-01983-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00066-022-01983-6" target="_blank" >10.1007/s00066-022-01983-6</a>

Result language

angličtina

Original language name

Long-term results of radio(chemo)therapy in metastatic carcinoma to cervical lymph nodes from an unknown primary. Adult Comorbidity Evaluation 27 score as a predictor of survival

Original language description

Purpose To evaluate the effectiveness and toxicity of curative (chemo)radiotherapy in patients with metastatic carcinoma to cervical lymph nodes from an unknown primary. Methods Retrospective study of 90 consecutive patients, treated with curative radiotherapy from 2003 to 2018 (median age 59 years; current/former smokers 76%) was conducted. The distribution of nodal staging was as follows: N1: 12%, N2a: 21%, N2b: 43%, N2c: 10%, N3: 13%. In 62% of patients, neck dissection was performed before radiotherapy. Concomitant chemotherapy was given to 64% of patients. Results The median follow-up of surviving patients was 86 months. The median total radiotherapy dose achieved was 70 Gy. The 5- and 10-year locoregional control were 84% in both cases, while 5- and 10-year distant control were 90% and 89%, respectively. A primary tumor in the head and neck area was detected in only 2 patients. No patient had an initial failure in the pharyngeal axis or contralateral cervical nodes. The 5- and 10-year overall survival were 55% and 42%, respectively. Severe early toxicity occurred in 71%; severe late toxicity in 33% of patients. Multivariate analysis demonstrated N-status (hazard ratio [HR] 2.424; 95% confidence interval [CI] 1.121-5.241; p = 0.024) and comorbidity scores assessed by ACE-27 (Adult Comorbidity Evaluation; HR 3.058; 95% CI 1.489-6.281; p = 0.002) as two independent prognostic factors for overall survival. Conclusion The results of our work study demonstrate the high effectiveness of curative (chemo)radiotherapy on the pharyngeal axis and bilateral cervical nodes with long-term locoregional and distant control in 3/4 of the treated patients. N-status and comorbidity scores were shown as strong prognostic factors influencing overall survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

STRAHLENTHERAPIE UND ONKOLOGIE

ISSN

0179-7158

e-ISSN

1439-099X

Volume of the periodical

199

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

149-159

UT code for WoS article

000837929200001

EID of the result in the Scopus database

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