Is shorter also better in the treatment of Clostridioides difficile infection?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F24%3AW0000018" target="_blank" >RIV/00064211:_____/24:W0000018 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43926985 RIV/00216208:11130/24:10479738 RIV/00064203:_____/24:10479738
Result on the web
<a href="https://oadoi.org/10.1093/jac/dkae119" target="_blank" >https://oadoi.org/10.1093/jac/dkae119</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jac/dkae119" target="_blank" >10.1093/jac/dkae119</a>
Alternative languages
Result language
angličtina
Original language name
Is shorter also better in the treatment of Clostridioides difficile infection?
Original language description
Objectives To assess the effectiveness of shortened regimens of vancomycin or fidaxomicin in the treatment of Clostridioides difficile infection (CDI).Methods Adult patients with CDI hospitalized from January 2022 to May 2023 were included in this observational study. In patients with CDI treated with vancomycin or fidaxomicin, antibiotic treatment was discontinued after either 5 or 7 days of vancomycin or 5 days of fidaxomicin if there was a clinical response and improvement in laboratory parameters. The control cohort was treated with the standard 10 day regimen of either vancomycin or fidaxomicin. The follow-up was 60 days. Causative C. difficile strains were characterized by ribotyping and toxin gene detection when available.Results Twenty-five patients (median age 76 years) received shortened treatment with vancomycin (n = 21), or fidaxomicin (n = 4). Five cases fulfilled the criteria for severe CDI. Twenty-three patients completed follow-up; two died from causes other than CDI, and two developed recurrent CDI (8.0%). Ribotypes (RTs) 001 and 014 were the most prevalent with 20% each. In two C. difficile isolates, binary toxin genes were detected (RTs 078 and 023). In the control group of 22 patients recurrent CDI developed in 5 patients (22.7%). No statistically significant differences were found between the groups.Conclusions Shortened treatment regimens for CDI with vancomycin and fidaxomicin were shown to be effective in our cohort of patients compared with 10 days of treatment. The recurrence rate was lower in the study group. A larger, prospective, double-blind, randomized, multicentre study is needed to support our findings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
ISSN
0305-7453
e-ISSN
1460-2091
Volume of the periodical
79
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
1413-1417
UT code for WoS article
001207874100001
EID of the result in the Scopus database
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