From Rapid Manufacturing to Clinical Use: A Retrospective Observational Study of an Emergency Ventilator During the COVID-19 Pandemic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F25%3AW0000016" target="_blank" >RIV/00064211:_____/25:W0000016 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/25:00385426 RIV/00216208:11120/25:43928858

Result on the web

<a href="https://oadoi.org/10.1017/dmp.2025.10194" target="_blank" >https://oadoi.org/10.1017/dmp.2025.10194</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/dmp.2025.10194" target="_blank" >10.1017/dmp.2025.10194</a>

Result language

angličtina

Original language name

From Rapid Manufacturing to Clinical Use: A Retrospective Observational Study of an Emergency Ventilator During the COVID-19 Pandemic

Original language description

Objective The COVID-19 pandemic spurred efforts to develop emergency ventilators, though few progressed beyond laboratory testing. This study evaluates CoroVent, a rapidly manufactured ventilator, during real-life deployment in critically ill COVID-19 patients amid ventilator shortages.Methods This retrospective observational study included patients ventilated with emergency ventilator CoroVent. This device uses a novel and unique way of generating inspiratory flow and gas mixing using fast ON/OFF valves for air and oxygen, producing pneumatic pulses that are then smoothed into continuous flow. Clinical data were collected from 3 hospitals between October 2020 and March 2021, selected from 27 contacted, of which 23 responded and 4 reported clinical use.Results Eight male patients (mean age 67 years, BMI 37.2 kg<middle dot>m-2) with COVID-19 or suspected infection were ventilated with CoroVent for 31.3 (10.0-58.5) hours. The mean FiO2 was 71.4%, PEEP 10.6 cmH2O, and Vt 8.9 mL<middle dot>kg-1 predicted body weight. CoroVent was used as an initial or replacement ventilator during device shortages. No major technical failures occurred.Conclusions This is the first report of real-life clinical use of a rapidly manufactured emergency ventilator during the COVID-19 pandemic. The results confirm that such devices, if well-designed, can provide effective respiratory support when conventional ventilators are unavailable.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS

ISSN

1935-7893

e-ISSN

1938-744X

Volume of the periodical

19

Issue of the periodical within the volume

SEP 24 2025

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

-

UT code for WoS article

001577069000001

EID of the result in the Scopus database

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