Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow's milk allergy patients with atopic dermatitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F25%3AW0000061" target="_blank" >RIV/00064211:_____/25:W0000061 - isvavai.cz</a>

Result on the web

<a href="https://oadoi.org/10.1016/j.isci.2025.113943" target="_blank" >https://oadoi.org/10.1016/j.isci.2025.113943</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.isci.2025.113943" target="_blank" >10.1016/j.isci.2025.113943</a>

Result language

angličtina

Original language name

Skin and gut microbiota composition and immune regulatory response differentiate IgE and non-IgE cow's milk allergy patients with atopic dermatitis

Original language description

Precise identification of food allergy and atopic dermatitis (AD) endotypes in infants is needed to target treatments effectively. Therefore, we investigated markers associated with changes in the microbiota and immune responses within the gut-skin axis of immunoglobulin E (IgE) and non-IgE-mediated cow's milk allergy (CMA) patients with AD. We report that the skin microbiota of patients with IgE CMA differs significantly from healthy controls (HCs) and from patients with non-IgE CMA, despite similar AD severity. Regarding the immune response to bacteria, we found a significant increase in soluble CD14 in patients with non-IgE CMA compared to patients with IgE CMA. Patients with a non-IgE CMA have more regulatory T cells in their blood that migrate into the intestine than patients with IgE CMA. These findings provide insights into the complex interplay between the damaged epithelial barrier, microbiome, and immune responses in CMA patients with AD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ISCIENCE

ISSN

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e-ISSN

2589-0042

Volume of the periodical

28

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

22

Pages from-to

-

UT code for WoS article

001633332700009

EID of the result in the Scopus database

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