Folate receptor alpha (FRα) expression in tubo-ovarian and endometrial tumors: a study of 923 cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F26%3AW0000069" target="_blank" >RIV/00064211:_____/26:W0000069 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/26:10001442

Result on the web

<a href="https://oadoi.org/10.1002/2056-4538.70087" target="_blank" >https://oadoi.org/10.1002/2056-4538.70087</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/2056-4538.70087" target="_blank" >10.1002/2056-4538.70087</a>

Result language

angličtina

Original language name

Folate receptor alpha (FRα) expression in tubo-ovarian and endometrial tumors: a study of 923 cases

Original language description

Folate receptor alpha (FR alpha) is a promising therapeutic target due to its high expression in several tumor types and its rare expression in healthy tissue. Recently, the antibody-drug conjugate mirvetuximab soravtansine has been approved for treatment of advanced platinum-resistant high-grade serous carcinoma (HGSC). Immunohistochemical expression of FR alpha has been extensively studied in HGSC, but most studies conducted before the clinical studies targeting FR alpha used variable antibodies and scoring criteria, which makes comparison of older literature data with recent studies difficult. Moreover, the data regarding its expression in other types of ovarian and other female genital tract tumors are limited or absent. In our study, we focused on immunohistochemical expression in 923 tubo-ovarian and endometrial tumors (assessed on tissue microarrays), using standardized scoring criteria and the VENTANA FOLR1 CDx assay. The results of our study showed the highest FR alpha expression in serous carcinomas, specifically HGSC (45% positive cases), followed by low-grade serous carcinoma (25%), endometrial serous carcinoma (11%), and serous borderline tumor (10%). Endometrioid and clear cell ovarian carcinomas showed rare positivity (2% and 1%, respectively). All other tumors examined were negative, including mucinous ovarian tumors, sex cord-stromal tumors, endometrial endometrioid carcinomas, undifferentiated and dedifferentiated carcinomas, and endometrial clear cell carcinomas. In conclusion, these results confirm that FR alpha expression in HGSC and LGSC reaches similar values compared to published data, and is present in a minority of endometrial serous carcinomas. In other ovarian and endometrial tumors examined, FR alpha expression is absent or rare.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2026

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF PATHOLOGY CLINICAL RESEARCH

ISSN

—

e-ISSN

2056-4538

Volume of the periodical

12

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

-

UT code for WoS article

001720434400001

EID of the result in the Scopus database

—