Cerebrospinal fluid levels of chromogranin A in the treatment-na < ve early stage Parkinson's disease: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F13%3A%230000502" target="_blank" >RIV/00098892:_____/13:#0000502 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/13:33145086

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cerebrospinal fluid levels of chromogranin A in the treatment-na < ve early stage Parkinson's disease: a pilot study

Original language description

Chromogranin A (CgA) levels in cerebrospinal fluid (CSF) have been reported to be significantly reduced in the later stages of Parkinson's disease (PD). There are only limited data regarding its levels in the early stages, so its significance as a potential biomarker in the diagnosis of PD cannot be established. The aim of our study was to establish the level of CgA in a cohort of treatment-na < ve patients with early stage PD. Ten patients (4 males, 6 females) and 10 gender- and age-matched controls were examined for CgA levels in the CSF. Control subjects were patients with low-back pain or tension-type headache. The mean CSF CgA level in PD patients was 74.8 (41.9-123.8) mu g/l; in the control group it was 143.9 (116-181.3) mu g/l. Statistical analysis showed a difference at the significance level P a parts per thousand currency sign 0.05. Our pilot study shows that CSF CgA levels are reduced in the early stages of PD. CgA could therefore be a potential biomarker helpful in the diag

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT12221" target="_blank" >NT12221: Markers of neurodegeneration in differential diagnosis of parkinsonian syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

120

Issue of the periodical within the volume

11

Country of publishing house

AT - AUSTRIA

Number of pages

5

Pages from-to

1559-1563

UT code for WoS article

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EID of the result in the Scopus database

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