Interaction of anthocyanins with human liver microsomal cytochromes P450

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F13%3A%230000548" target="_blank" >RIV/00098892:_____/13:#0000548 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction of anthocyanins with human liver microsomal cytochromes P450

Original language description

Anthocyanins are pigments present in fruit and vegetables. Antocyanins are glycosides; their aglycones are flavonoids, anthocyanidins (the most common are cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin). In this preliminary report theinhibition of three forms of human liver microsomal CYPs was studied. The CYP3A4 activity was influenced the most being inhibited to about 60% of the original activity by most of the anthocyanins at the highest concentration tested.. Inhibition of CYP2C9 enzyme activity was more prominent with delphinidin-3-glucoside and cyanidin-3-galactoside (down to 60 % of the original activity), CYP1A2 enzyme was inhibited in a small extent. The results indicate that the interactions of anthocyanins with liver CYPenzymes most probably does not pose any harm to human organism based on drug interactions; however, in case of drugs metabolized by CYP3A4, and an ingestion of large amounts of anthocyanins, a limited increase of drug bioavailability may

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

"S56"-"S59"

UT code for WoS article

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EID of the result in the Scopus database

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