Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000037" target="_blank" >RIV/00098892:_____/16:N0000037 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/16:33160090

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients

Original language description

A total of 104 patients stabilised after kidney transplantation were converted from maintenance therapy with cyclosporine to treatment with tacrolimus prolonged release (brand name Advagraf) Results of the first six months after the conversion are given. The primary endpoint was change in glomerular filtration rate, which increased after six months by 10 % (p=0,040). In addition a significant decrease of serum creatinine and urea levels, decrease of triglycerides level were noticed. There was an important decline in incidence and severity of gingival hyperplasia and hirsutism. 3 % patients developed a new onset of diabetes mellitus. The switch was very well tolerated, without serious adverse events or acute rejections. Conversion from cyclosporine to tacrolimus prolonged release has shown to be a safe therapeutic alternative with possible benefits for the patient

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Volume of the periodical

160

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

407-411

UT code for WoS article

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EID of the result in the Scopus database

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