Prognostic significance of serum and urinary neopterin concentrations in patients with rectal carcinoma treated with chemoradiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F16%3AN0000047" target="_blank" >RIV/00098892:_____/16:N0000047 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/16:10319132 RIV/61989592:15110/16:33160437 RIV/00179906:_____/16:10319132

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prognostic significance of serum and urinary neopterin concentrations in patients with rectal carcinoma treated with chemoradiation

Original language description

Aim: To analyze the prognostic significance of serum and urinary neopterin concentrations in patients with rectal adenocarcinoma treated with (chemo) radiation. Patients and Methods: Urinary and serum neopterin and peripheral blood cell count were determined in 49 patients with rectal carcinoma before the start of (chemo) radiation. Results: Neopterin concentrations exhibited a significant inverse correlation with hemoglobin and positive correlation with leukocyte count, platelet count and platelet-to-lymphocyte ratio. Increased serum neopterin concentration was associated with significantly inferior relapse-free survival (RFS) and overall survival. However, a significant association was observed only in 28 patients treated in the neoadjuvant setting. Although increased urinary neopterin was also associated with inferior RFS and overall survival, this was not statistically significant. The neutrophil-to-lymphocyte ratio was also associated with poor prognosis. Conclusion: The data presented herein indicate a prognostic significance of serum neopterin concentrations in patients with rectal cancer treated with neoadjuvant chemoradiation

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/LO1304" target="_blank" >LO1304: Support of suistainability of the Institute of Molecular and Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

287-292

UT code for WoS article

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EID of the result in the Scopus database

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