Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000081" target="_blank" >RIV/00098892:_____/18:N0000081 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/18:73589957

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

Original language description

Objectives. Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). Methods. Thirty-two patients with ON due to MS within 3months of onset of symptoms were enrolled [22 females, 10 males, age 349years, median 32.5years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint((R)), Minneapolis, MN, USA). Results. Arterio-venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) 34.2 plus minus 4.7 versus 31.3 plus minus 4.6, p=0.044 (mean plus minus standard deviation). No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p<0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS. Conclusion. The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Ophthalmologica

ISSN

1755-375X

e-ISSN

—

Volume of the periodical

96

Issue of the periodical within the volume

3

Country of publishing house

DK - DENMARK

Number of pages

6

Pages from-to

309-314

UT code for WoS article

000430912700007

EID of the result in the Scopus database

2-s2.0-85032811888