The role of nCD64 in the diagnosis of neonatal sepsis in preterm newborns
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000124" target="_blank" >RIV/00098892:_____/18:N0000124 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/18:73590211 RIV/61989592:15310/18:73590211
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The role of nCD64 in the diagnosis of neonatal sepsis in preterm newborns
Original language description
BACKGROUND: Diagnosing neonatal sepsis is difficult, particularly in preterm newborns. A promising method appears to be evaluation of cell surface markers by flow cytometry. METHODS: This prospective study investigated 217 newborns suspected of having early- or late-onset neonatal sepsis. In all, flow cytometry was used to determine the proportion of CD64-positive neutrophils (nCD64). Based on the clinical course and laboratory test results, newborns were categorized as having proven, possible, clinical or no neonatal sepsis. Subsequently, associations between the categories and nCD64 values were analyzed. RESULTS: There were significant associations between nCD64 values and the development of sepsis in newborns with both early- or late-onset sepsis. CONCLUSION: nCD64expression is significantly elevated in preterm newborn with early and late onset sepsis. The results show that nCD64 is a reliable marker for diagnosing neonatal sepsis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers - Olomouc
ISSN
1213-8118
e-ISSN
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Volume of the periodical
162
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
284-288
UT code for WoS article
000457488200006
EID of the result in the Scopus database
2-s2.0-85057323682