Granulocyte transfusions collected after steroid priming for severe infections during neutropenia: A single center experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000012" target="_blank" >RIV/00098892:_____/19:N0000012 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/19:73589083 RIV/61988987:17110/19:A21026F1

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1246782018302738" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1246782018302738</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tracli.2018.09.001" target="_blank" >10.1016/j.tracli.2018.09.001</a>

Result language

angličtina

Original language name

Granulocyte transfusions collected after steroid priming for severe infections during neutropenia: A single center experience

Original language description

BACKGROUND: There is no universally accepted opinion on the use of granulocyte transfusions collected using apheresis (GTA) in neutropenic patients and severe infection. PATIENTS AND METHODS: The efficacy and safety of GTAs transfused at a single center over 10 years were analyzed retrospectively. GTAs were harvested from voluntary unrelated donors after priming with methylprednisolone using continuous apheresis and hydroxyethylstarch as sedimentation agent. RESULTS: 41 patients with neutropenia and hematologic malignancy (15 females and 26 males aged 22-69 (median 45.5)) were given a median 3.5 GTAs per patient (range: 1-17) containing a median 1.39×1010 granulocyte/GTA (range: 0.65-2.81). The indications for GTA use were soft tissue inflammation, sepsis, and pneumonia in 30, 22, and 14 cases, respectively. After GTA complete (30 patients: 73.2%) or partial (6 patients: 14.6%) healing of the infection was achieved. The success rate was 91.7% in soft tissue infections, 66.7% in invasive fungal infections, and 68% in sepsis. Septic shock (documented in 12 cases) was associated with a poor response (P<0.03; Chi-square test). Clinical worsening was observed in six cases (14.6%); four patients died. No significant short-term side effects of GTA treatment were recorded. CONCLUSIONS: In our study GTAs collected after steroid priming and used for the treatment of infection during severe neutropenia have shown comparable efficacy with several previously reported trials. However retrospective fashion of our study and inhomogeneous group of patients do not allow any firm conclusions. Prospective studies (including patients' registries) are needed for the better clarification of the role and the dose of GTAs necessary for the successful infection management during neutropenia.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

TRANSFUSION CLINIQUE ET BIOLOGIQUE

ISSN

1246-7820

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

4

Country of publishing house

FR - FRANCE

Number of pages

5

Pages from-to

299-303

UT code for WoS article

000504370600020

EID of the result in the Scopus database

2-s2.0-85055127135