Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F19%3AN0000092" target="_blank" >RIV/00098892:_____/19:N0000092 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00111746 RIV/61989592:15110/19:73598732 RIV/61988987:17110/19:A21025BX

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1043466617300820?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1043466617300820?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cyto.2017.03.016" target="_blank" >10.1016/j.cyto.2017.03.016</a>

Result language

angličtina

Original language name

Plasma levels and leucocyte RNA expression of adipokines in young patients with coronary artery disease, in metabolic syndrome and healthy controls

Original language description

Objectives: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. Design and methods: Sixty-five patients with premature CAD (men 18-45 years old and women 18-55 years old) formed the study group. The control groups were 75 patients with metabolic syndrome and 50 healthy individuals. For each group, RNA expression in peripheral blood leukocytes was determined for 24 different adipokines and 11 adipokines were examined in serum. Results: In individuals with CAD, serum visfatin levels were significantly higher than in metabolic syndrome and healthy controls (2.3 vs. 1.6 vs. 0.7 mu g/L, P < 0.001) while both omentin-1 (92.9 vs. 587.0 vs. 552.3 mu g/L, P < 0.001) and ZAG2 (45.5 vs. 72.5 vs. 77.1 mg/L, P < 0.001) levels were lower. The receiver operating curve (ROC) analysis for testing the validity of these adipokines in the diagnosis of CAD compared to control groups provided the following areas under the curve (AUC): omentin-1 AUC 0.97 (cut-off <= 222 mu g/L), ZAG2 AUC 0.89 (cut-off <= 51.7 mg/L) and visfatin AUC 0.74 (cut-off >= 1.0 mu g/L) (P < 0.001 in all cases). Visfatin and omentin-1 serum levels did not differ between the acute phase of myocardial infarction and the chronic phase of CAD. In patients with CAD, we found no significant relation between mRNA expression and adipokine concentration. Conclusion: Serum omentin-1, visfatin and ZAG2 could serve as biomarkers of premature CAD in young apparently healthy people.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CYTOKINE

ISSN

1043-4666

e-ISSN

1096-0023

Volume of the periodical

122

Issue of the periodical within the volume

SI (October)

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

154017

UT code for WoS article

000488662600003

EID of the result in the Scopus database

2-s2.0-85017464660