Risk of recurrent ischemic stroke in young cryptogenic patients with embolic stroke of undetermined source

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F20%3AN0000115" target="_blank" >RIV/00098892:_____/20:N0000115 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/20:73603729

Result on the web

<a href="https://www.jns-journal.com/action/showPdf?pii=S0022-510X%2820%2930322-1" target="_blank" >https://www.jns-journal.com/action/showPdf?pii=S0022-510X%2820%2930322-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2020.116985" target="_blank" >10.1016/j.jns.2020.116985</a>

Result language

angličtina

Original language name

Risk of recurrent ischemic stroke in young cryptogenic patients with embolic stroke of undetermined source

Original language description

Introduction: Elderly cryptogenic ischemic stroke (IS) patients with embolic stroke of undetermined source (ESUS) have a high risk of recurrent IS (RIS) compared to other stroke subtypes. In young ESUS patients, different sources of embolism may be a cause and the risk of RIS remains not enough established. The aim was to assess and compare risk of RIS between ESUS and non ESUS patients <50 years. Methods: The study set consisted of young acute IS patients <50 years enrolled in the prospective HISTORY (Heart and Ischemic STrOke Relationship studY) study registered on ClinicalTrials.gov (NCT01541163). In all analyzed patients, the brain ischemia was confirmed on CT or MRI. All patients underwent identical diagnostic protocol including TEE and long-term ECG-Holter. Cause of IS was assessed according to the ASCOD classification. Results: Of 320 enrolled patients <50 years, 219 (68.4%) were identified as cryptogenic (119 males, mean age 41.4 ± 7.2 years) and 122 (38.1%) patients fulfilled the ESUS criteria. During the follow-up with a median of 34 months, three (2.5%) ESUS and 5 (5.2%) non-ESUS patients suffered from RIS (p = .471). One-year risk of RIS was 0.008 (95% CI: 0–0.025) for ESUS and 0.036 (95% CI: 0–0.076) for non-ESUS patients (p = .262). Conclusion: The risk of RIS was very low in ESUS patients and did not differ from those with non-ESUS. Our finding may indicate that antiplatelet therapy can be effective in the secondary prevention in young ESUS patients if high-risk sources of embolization are excluded extensively.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV17-30101A" target="_blank" >NV17-30101A: Risk factors of ischemic stroke in young patients and relation with epidemiologic, social and economic parameters and life style</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

1878-5883

Volume of the periodical

416

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

116985

UT code for WoS article

000596476500049

EID of the result in the Scopus database

2-s2.0-85086523224