Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000016" target="_blank" >RIV/00098892:_____/21:N0000016 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00122107 RIV/00216208:11150/21:10422062 RIV/65269705:_____/21:00074449 RIV/00064211:_____/21:W0000015 and 2 more

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202102-0004_introducing-a-new-prognostic-instrument-for-long-term-mortality-prediction-in-copd-patients-the-cadot-index.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2020.035" target="_blank" >10.5507/bp.2020.035</a>

Result language

angličtina

Original language name

Introducing a new prognostic instrument for long-term mortality prediction in COPD patients: the CADOT index

Original language description

Objectives. The BODE (BMI, Obstruction - FEV1, Dyspnoea – mMRC, Exercise – 6-MWT) and the ADO (Age, Dyspnoea – mMRC, Obstruction – FEV1) indices are widely used prognosis assessment tools for long-term mortality prediction in COPD patients but subject to limitations for use in daily clinical practice. The aim of this research was to construct a prognostic instrument that prevents these limitations and which would serve as a complementary prognostic tool for clinical use in these patients. Methods and Participants. The data of 699 COPD subjects were extracted from the Czech Multicentre Research Database (CMRD) of COPD patients (the derivation cohort) and analysed to identify factors associated with the long-term risk of mortality. These were entered into the ROC analysis and reclassification analysis. Those with the strongest discriminative power were used to construct the new index (CADOT). The new index was validated on 187 patients of the CIROCO+ cohort (Netherlands; the validation cohort). Results. The CADOT was constructed by adding two newly identified prognosis-determining factors, chronic heart failure (CHF) and TLCO, to the ADO index. In a head-to-head comparison, the CADOT index showed highest c-statistic values compared to the BODE and ADO indices (0.701 vs 0.677 vs 0.644, respectively). The prognostic power was more definitive when applied to the Dutch validation (CIROCO+) cohort (0.842 vs 0.799 vs 0.825, respectively). Conclusions. The CADOT index has comparable prognostic power to the BODE and ADO indices. The CADOT is complementary/an alternative to the BODE (if 6-MWT is not feasible) and ADO (with less dependence on the age factor) indices. Trial registration: ClinicalTrials.gov (NCT01923051).

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc  

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

165

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

139-145

UT code for WoS article

000660244900004

EID of the result in the Scopus database

2-s2.0-85097737169