Sustained efficacy of incobotulinumtoxina following repeated injections for upper-limb post-stroke spasticity: A post hoc analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000203" target="_blank" >RIV/00098892:_____/21:N0000203 - isvavai.cz</a>
Result on the web
<a href="https://www.medicaljournals.se/jrm/content/abstract/10.2340/16501977-2760?ref=search" target="_blank" >https://www.medicaljournals.se/jrm/content/abstract/10.2340/16501977-2760?ref=search</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2340/16501977-2760" target="_blank" >10.2340/16501977-2760</a>
Alternative languages
Result language
angličtina
Original language name
Sustained efficacy of incobotulinumtoxina following repeated injections for upper-limb post-stroke spasticity: A post hoc analysis
Original language description
Objective: This post hoc analysis assessed the impact of repeated incobotulinumtoxinA injections on muscle tone, disability, and caregiver burden in adults with upper-limb post-stroke spasticity. Design: Data from the double-blind, placebo-controlled main period and three open-label extension cycles of two Phase 3, randomized, multicentre trials were pooled. Methods: Subjects received incobotulinumtoxinA 400 Units at 12-week intervals (±3 days) (study 3001, NCT01392300) or ≤ 400 Units at ≥12-week intervals based on clinical need (study 0410, NCT00432666). Ashworth Scale (AS) arm sumscore (sum of elbow, wrist, finger and thumb flexor, and forearm pronator AS scores), Disability Assessment Scale (DAS), and Carer Burden Scale (CBS) scores were assessed. Results: Among 465 subjects, from study baseline to 4 weeks post-injection, mean (standard deviation) AS arm sumscore improved continuously: main period, -3.23 (2.55) (placebo, -1.49 (2.09)); extension cycles 1, 2, and 3, -4.38 (2.85), -4.87 (3.05), and -5.03 (3.02), respectively. DAS principal target domain responder rate increased from 47.4% in the main period (placebo 27.2%) to 66.6% in extension cycle 3. Significant improvements in CBS scores 4 weeks post-injection accompanied improved functional disability in all cycles. Conclusion: IncobotulinumtoxinA conferred sustained improvements in muscle tone, disability, and caregiver burden in subjects with upper-limb post-stroke spasticity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Rehabilitation Medicine
ISSN
1650-1977
e-ISSN
1651-2081
Volume of the periodical
53
Issue of the periodical within the volume
1
Country of publishing house
SE - SWEDEN
Number of pages
7
Pages from-to
jrm00138
UT code for WoS article
000607026400003
EID of the result in the Scopus database
2-s2.0-85099427806