COVID-19 in 96 Patients With Hematologic Disease: The First Single-center Experience From the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000223" target="_blank" >RIV/00098892:_____/21:N0000223 - isvavai.cz</a>

Result on the web

<a href="https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(21)00176-2/fulltext" target="_blank" >https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(21)00176-2/fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clml.2021.04.016" target="_blank" >10.1016/j.clml.2021.04.016</a>

Result language

angličtina

Original language name

COVID-19 in 96 Patients With Hematologic Disease: The First Single-center Experience From the Czech Republic

Original language description

Background: Coronavirus disease 2019 (COVID-19) represents an important infectious complication associated with high mortality rates in patients with hematologic diseases. There have not been published any epidemiologic studies from Czech Republic so far. Patients and Methods: This study is the first analysis of patients with hematologic malignancies and bone marrow failure syndromes treated at single hematology center in the Czech Republic between March 1 and December 31, 2020, in whom COVID-19 infection was confirmed. Results: The sample comprised 96 patients aged 26 to 84 years (median, 66.0 years). At the time of their COVID-19 diagnosis, 75 patients (78.1%) were treated for hematologic diseases. Twenty-seven patients (28.1%) in the sample had complete remission (CR) of their hematologic disease. They were nonsignificantly more likely to have asymptomatic to moderate COVID-19 infection than those who failed to achieve CR (74.1% vs. 56.5%; P = .06). A more severe course of the infection was significantly correlated with older age (P = .047). Lung involvement was also statistically significantly associated with older age (P = .045). Over the study period, a total of 15 patients died. Age greater than 60 years was significantly associated with deaths from COVID-19 (P = .036), with failure to achieve CR having a statistically nonsignificant impact on mortality (P = .22). Conclusion: These results confirm the prognostic significance of age for achieving treatment response of hematologic disease as well as the severity and mortality of COVID-19 in hematology patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Lymphoma, Myeloma and Leukemia

ISSN

2152-2650

e-ISSN

2152-2669

Volume of the periodical

21

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

606-612

UT code for WoS article

000690403800013

EID of the result in the Scopus database

2-s2.0-85108190391