Lung hyperinflation in patients with obstructive sleep apnoea treated with continuous positive airway pressure – preliminary safety data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000232" target="_blank" >RIV/00098892:_____/21:N0000232 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/21:73608310

Result on the web

<a href="http://www.pneumologie.cz/cislo/1892/3-2021/" target="_blank" >http://www.pneumologie.cz/cislo/1892/3-2021/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lung hyperinflation in patients with obstructive sleep apnoea treated with continuous positive airway pressure – preliminary safety data

Original language description

Objective: Continuous positive airway pressure (CPAP) is currently the gold standard treatment for obstructive sleep apnea (OSA). One of the possible side effects of this therapy may be lung hyperinflation. The aim of this study was to assess the effect of CPAP on lung hyperinflation in patients with OSA. Method: Fifty consecutive OSA patients (43 males) of a mean age of 53.4 years were enrolled into this pilot study. All patients had two body plethysmography measurements taken, one at the time of OSA diagnosis (with AHI > 15), and another after three months of CPAP therapy. Sufficient compliance with therapy was defined as a CPAP use of more than 4 hours per night. Lung hyperinflation was assessed by the residual volume/total lung capacity ratio (RV/TLC). Results: The study found a significant increase in the RV/TLC ratio in CPAP-compliant patients (p = 0.03). The increase did not correlate with the amount of pressure used. The RV/TLC ratio was within physiological ranges both before and after CPAP therapy (mean ratios of 0.38 and 0.40 before and after CPAP therapy, respectively). Conclusion: According to our results, clinically non-significant lung hyperinflation should be considered a possible side effect of CPAP therapy. However, given the small sample size and the minimal difference in the RV/TLC ratio, this conclusion should be verified in a further larger and longer prospective study.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30203 - Respiratory systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Studia Pneumologica et Phthiseologica

ISSN

1213-810X

e-ISSN

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Volume of the periodical

81

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

121-125

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85170225826