Interventional prevention of paradoxical embolism as the gold standard: End of discussion?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000235" target="_blank" >RIV/00098892:_____/21:N0000235 - isvavai.cz</a>

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-202103-0002_interventional-prevention-of-paradoxical-embolism-as-the-gold-standard-end-of-discussion.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202103-0002_interventional-prevention-of-paradoxical-embolism-as-the-gold-standard-end-of-discussion.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2021.036" target="_blank" >10.5507/bp.2021.036</a>

Result language

angličtina

Original language name

Interventional prevention of paradoxical embolism as the gold standard: End of discussion?

Original language description

Paradoxical embolism is one of the predominant causes of cryptogenic stroke and interventional secondary prevention, i.e., closure of the patent foramen ovale (PFO), is a much discussed issue. This review aims to provide a complex perspective on this topic, aggregates and comments on the available data and current guidelines. Several large trials were performed, some of which proved the superiority of PFO closure over pharmacotherapy while others have not. Studies detecting significant superiority of intervention worked with disproportionately high representation of large shunts compared to the general population. Other controversies also remain, such as the lack of comparison of the effect of modern anticoagulant/antiplatelet treatment to PFO closure or the risk of developing unwanted side effects after intervention, and these are discussed in detail. PFO closure is a suitable method for secondary prevention of paradoxical embolism and, therefore, cryptogenic stroke. However, this is only true for carefully selected patient populations and such selection is of the utmost importance in deciding on interventional or conservative treatment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers-Olomouc  

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

165

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

 241-248

UT code for WoS article

000715922000002

EID of the result in the Scopus database

2-s2.0-85115703681