Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157732" target="_blank" >RIV/00098892:_____/22:10157732 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/22:73609395
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-202201-0001_which-bacterial-toxins-are-worthy-of-validation-as-markers-in-colorectal-cancer-screening-a-critical-review.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202201-0001_which-bacterial-toxins-are-worthy-of-validation-as-markers-in-colorectal-cancer-screening-a-critical-review.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2021.054" target="_blank" >10.5507/bp.2021.054</a>
Alternative languages
Result language
angličtina
Original language name
Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review
Original language description
Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of asymptomatic cases in the population aged 50+. Therefore, there is still a demand for new screening tests that would complement FOBT, mainly by detecting at least a part of the FOBT-negative CRC and adenoma cases, or possibly by identifying person at increased risk of sporadic CRC in order to offer them tailored follow-up. Among the potential markers studied, our knowledge has advanced at most in toxigenic gram-negative bacteria. In this review, we assess their potential critically and recommend those best suited for prospective evaluation of their true ability to increase the sensitivity of FOBT when combined during general population screening. In our opinion, colibactin and Bacteroides fragilis toxin are the best candidates, possibly complemented by the cytotoxic necrotizing factor (CNF).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV19-03-00069" target="_blank" >NV19-03-00069: Correlation of immunotherapeutic molecular targets with gut microbiome in NSCLC patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers-Olomouc
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
166
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
1-11
UT code for WoS article
000731340000001
EID of the result in the Scopus database
2-s2.0-85126490980