The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157733" target="_blank" >RIV/00098892:_____/22:10157733 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/22:73611872
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-202203-0001_the-use-of-biomarkers-in-the-diagnosis-and-treatment-of-obstruction-of-the-upper-urinary-tract-in-children.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202203-0001_the-use-of-biomarkers-in-the-diagnosis-and-treatment-of-obstruction-of-the-upper-urinary-tract-in-children.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2022.002" target="_blank" >10.5507/bp.2022.002</a>

Result language
angličtina
Original language name
The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children
Original language description
Antenatal hydronephrosis, dilatation of the upper urinary tract (UUTD), is a common finding on prenatal ultrasound. One of the most common causes is ureteropelvic junction (UPJ) obstruction. Although such prenatally diagnosed UUTD resolves spontaneously in most newborns, further examination of these children is advocated to prevent possible irreversible kidney damage, and ultrasound is mainly used for this. If the dilatation persists or becomes symptomatic, it is necessary to proceed to other relatively demanding and invasive diagnostic examinations for these small patients, where the question of the right timing of indications for possible surgical solutions is still unclear. For this reason, various biomarkers have been investigated in a number of clinical trials as potential mini-invasive diagnostic tools for determining when upper urinary tract dilatation in such children poses a threat to the developing kidneys and they should be operated on, and vice versa, when to proceed conservatively. The aim of this article is to review the findings on and current issues with the use of biomarkers in the diagnosis and treatment of UPJ obstruction in children.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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