Environmental Factors in the Etiology of Mental Disorders in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10157942" target="_blank" >RIV/00098892:_____/23:10157942 - isvavai.cz</a>
Result on the web
<a href="https://www.dovepress.com/environmental-factors-in-the-etiology-of-mental-disorders-in-the-czech-peer-reviewed-fulltext-article-NDT" target="_blank" >https://www.dovepress.com/environmental-factors-in-the-etiology-of-mental-disorders-in-the-czech-peer-reviewed-fulltext-article-NDT</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/NDT.S379811" target="_blank" >10.2147/NDT.S379811</a>
Alternative languages
Result language
angličtina
Original language name
Environmental Factors in the Etiology of Mental Disorders in the Czech Republic
Original language description
Background: Both genetic and environmental factors are important in etiology of mental disorders. Calculating polyenviromic risk/protective scores provides an updated perspective in research on the environmental causes of psychiatric disorders. We aimed to compare environmental risk and protective factors in patients with psychosis or a mood disorder (PSYCH+MOOD) and those with an anxiety disorder (ANX). Methods: We administered the internationally accepted questionnaire from the EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study, enriched with mood and anxiety disorder-relevant measures, to patients at two large university hospitals in the Czech Republic. Results: Ninety-four PSYCH+MOOD patients (average age 42.5 years; 46 males) and 52 ANX patients (average age 47.2 years; 17 males) participated. Neither polyenviromic risk score nor polyenviromic protective score differed significantly between PSYCH +MOOD and ANX groups (p = 0.149; p = 0.466, respectively). Conclusion: Scientific validity of the polyenviromic risk/protective score construct must still be demonstrated in large psychiatric samples, ideally in prospective studies. Nevertheless, researchers have already started to investigate environmental factors in the etiology of mental disorders in their complexity, similarly to polygenic risk scores.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuropsychiatric Disease and Treatment
ISSN
1178-2021
e-ISSN
1178-2021
Volume of the periodical
19
Issue of the periodical within the volume
February
Country of publishing house
NZ - NEW ZEALAND
Number of pages
11
Pages from-to
349-359
UT code for WoS article
000928495600001
EID of the result in the Scopus database
2-s2.0-85147660159