DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10157949" target="_blank" >RIV/00098892:_____/23:10157949 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/23:10465030 RIV/61989592:15110/23:73622902 RIV/75010330:_____/23:00014250
Result on the web
<a href="https://www.mdpi.com/1422-0067/24/10/8868" target="_blank" >https://www.mdpi.com/1422-0067/24/10/8868</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms24108868" target="_blank" >10.3390/ijms24108868</a>
Alternative languages
Result language
angličtina
Original language name
DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC
Original language description
DNA repair pathways are essential for maintaining genome stability, and understanding the regulation of these mechanisms may help in the design of new strategies for treatments, the prevention of platinum-based chemoresistance, and the prolongation of overall patient survival not only with respect to ovarian cancer. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) together with cytoreductive surgery (CRS) and adjuvant systemic chemotherapy is receiving more interest in ovarian cancer (OC) treatment because of the typical peritoneal spread of the disease. The aim of our study was to compare the expression level of 84 genes involved in the DNA repair pathway in tumors and the paired peritoneal metastasis tissue of patients treated with CRS/platinum-based HIPEC with respect to overall patient survival, presence of peritoneal carcinomatosis, treatment response, and alterations in the BRCA1 and BRCA2 genes. Tumors and metastatic tissue from 28 ovarian cancer patients collected during cytoreductive surgery before HIPEC with cisplatin were used for RNA isolation and subsequent cDNA synthesis. Quantitative real-time PCR followed. The most interesting findings of our study are undoubtedly the gene interactions among the genes CCNH, XPA, SLK, RAD51C, XPA, NEIL1, and ATR for primary tumor tissue and ATM, ATR, BRCA2, CDK7, MSH2, MUTYH, POLB, and XRCC4 for metastases. Another interesting finding is the correlation between gene expression and overall survival (OS), where a low expression correlates with a worse OS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NU22-08-00186" target="_blank" >NU22-08-00186: Integromics concept in prediction of ovarian cancer therapy outcome and new therapeutic target identification</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
1422-0067
Volume of the periodical
24
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
8868
UT code for WoS article
000997191200001
EID of the result in the Scopus database
2-s2.0-85160404081