Acute drug intoxication in childhood: a 10-year retrospective observational single-centre study and case reports

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158006" target="_blank" >RIV/00098892:_____/23:10158006 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/23:73619637

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-202303-0011_acute-drug-intoxication-in-childhood-a-10-year-retrospective-observational-single-centre-study-and-case-report.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202303-0011_acute-drug-intoxication-in-childhood-a-10-year-retrospective-observational-single-centre-study-and-case-report.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2023.032" target="_blank" >10.5507/bp.2023.032</a>

Result language

angličtina

Original language name

Acute drug intoxication in childhood: a 10-year retrospective observational single-centre study and case reports

Original language description

Background. Medication poisoning in children is a severe condition that can endanger a child&apos;s life. Although drug intoxications are easily preventable, awareness of the proper handling of drugs and their safe storage out of the reach of children is not widespread among the general public. In this work, we investigated the demographic and clinical data of children admitted to the Department of Pediatrics of the University Hospital Olomouc for acute drug-induced intoxication. We also selected several case reports to illustrate the wide range of both presentations and outcomes in individual patients. Method. Cases of drug-induced intoxications were selected from a group of patients under the age of 19 years admitted to the hospital for poisoning between January 1, 2010, and December 31, 2019. Medical records of these patients were prospectively evaluated, and overview tables and graphs of predefined research objectives were created. Results. During the given time period, 162 children with suspected drug intoxications were hospitalized at the Department of Pediatrics, University Hospital Olomouc. Of these, 108 cases were reported in girls and 54 in boys (66.7% vs. 33.3%). In 16 cases (9.9%), there was a severe intoxication requiring follow-up intensive care. There was also one case of fatal accidental intoxication. Most poisonings were seen in toddlers (65; 40.1%). Intoxication with suicidal ideation was found in 44 cases (27.2%), with a higher incidence of suicide attempts in girls (40 vs. 4). Repeated intoxication was recorded in nine cases. Analgesics were the most common drug group (61; 37.7%), with paracetamol (28; 17.3%) being the leading drug. In 154 cases (95.1%), the drugs were taken orally, most often in the form of tablets. Conclusion. Accidental drug intoxications most frequently occurred in the age group from one to three years old. The second highest incidence was among adolescents most of which were suicide attempts. Analgesics and psychoactive agents accounted for the majority of cases. Medications should be kept in places where children cannot reach them.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

167

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

294-302

UT code for WoS article

001049359600001

EID of the result in the Scopus database

2-s2.0-85174550156