Medical Termination of Pregnancy (MToP) in the 1st trimester – the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F23%3A10158258" target="_blank" >RIV/00098892:_____/23:10158258 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/23:73622106

Result on the web

<a href="https://redakce.carecomm.cz/cgyn/article/view/2108" target="_blank" >https://redakce.carecomm.cz/cgyn/article/view/2108</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccg2023420" target="_blank" >10.48095/cccg2023420</a>

Result language

angličtina

Original language name

Medical Termination of Pregnancy (MToP) in the 1st trimester – the role of human chorionic gonadotropin and ultrasound in pregnancy diagnosis and MToP follow-up

Original language description

Objective: In the Czech Republic, it is possible, to carry out Medical Termination of Pregnancy (MTOP) in the 1st trimester up until the 49th day of secondary amenorrhea. The aim of the study is to analyse the significance of serum/urine human chorionic gonadotropin (hCG) assessment and ultrasound (US) examination in pregnancy diagnosis and MTOP follow-up. Methods: In 2017–2018, MTOP was carried out in a total of 109 women by administering a combination of mifepristone (600 mg orally) and misoprostol (400 mcg orally). Serum/urine (LSUP-low sensitivity urine pregnancy test) hCG assessment and US examination were performed at pregnancy diagnosis and MTOP follow-up. Results: At pregnancy diagnosis, there was a positive and medium strong correlation between serum hCG and size of the gestational sac – GS (R = 0.711; P &lt; 0.0001) and crown-rump length of the embryo – CRL (R = 0.605; P &lt; 0.0001). Gestational age was 42–49 days (average 45.6, median 45 days), the women were 16–44 years of age (average 29.4, median 29 years). In MTOP follow-up, serum hCG level was &gt; 1,000 IU/L in 13.8% of women (15/109) and a positive LSUP test in 17.4% (20/109). US examination diagnosed ongoing pregnancy in five women and missed abortion in one woman (serum hCG was always &gt; 1,000 IU/L and LSUP test was always positive). In 5.5% of women (6/109), a subsequent surgical intervention was carried out including those with ongoing pregnancy (N = 5); missed abortion (N = 1) was treated by additional misoprostol, where surgical intervention was not necessary. Conclusion: At pregnancy diagnosis, there is a positive and medium strong correlation between serum hCG and CRL. In MTOP follow-up, a negative LSUP test enables reliable exclusion of ongoing pregnancy and missed abortion. In case of a positive LSUP test, US examination should be performed; however, surgical intervention should not be indicated solely on the basis of uterine cavity dilatation.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká gynekologie

ISSN

1210-7832

e-ISSN

1805-4455

Volume of the periodical

88

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

420-427

UT code for WoS article

001179280900001

EID of the result in the Scopus database

2-s2.0-85181764864